introduction: glycoprotein b (gb) is the major antigen for induction of humoral responses against human cytomegalovirus (hcmv) making it an attractive candidate for immune prophylaxis. in the present study, the humoral immune response of balb/c mice to a truncated hcmv gb protein fused with gfp was evaluated. methods: the truncated gb coding sequence was synthesized and cloned in pegfpn1 eukary...

background and aims: glycoprotein b (gb) is among the most important immunogenic proteins of hsv-1 that is now being used as recombinant vaccine to induce protectively against the virus. it is believed that gb is responsible for induction of neutralizing antibody and up to 90% of ctl (cytotoxic t cell) activity against hsv-1 in some haplotypes. methods: in the present study the antibody titer i...

The nine-banded armadillo (Dasypus novemcinctus mexicanus Peters) was chosen for this study so that a comparison could be made of the salivary mucus glycoproteins of an ancient mammalian species with those derived from previously studied, more highly evolved species. Two mucus glycoproteins, armadillo submandibular glycoprotein A and armadillo submandibular glycoprotein B, were prepared from th...

Two glycoprotein fractions, A and B, were isolated from bovine achilles tendon. Glycoprotein A was prepared from a 0.2m-sodium chloride extract and glycoprotein B was isolated from a 3m-magnesium chloride extract. They were free from serum proteins. Glycoprotein A was essentially free of collagen, but glycoprotein B contained about 8% collagen. Both glycoproteins gave several bands on isoelectr...

The present study explores the efficacy of plant-derived natural products (PDNPs) against spike glycoproteins (S-glycoprotein) SARS-CoV-2 variants using molecular docking, ADMET, dynamics (MD) simulation and density-functional theory (DFT) analysis. In all, 100 PDNPs were screened glycoprotein variants, namely alpha (B.1.1.17), beta (B.1.351), delta (B.1.617), gamma (P.1) omicron (B.1.1.529). R...

The clinical manifestations in cytomegalovirus infected-infants vary from asymptomatic illness to highly fatal cytomegalic inclusion disease. The influence of human cytomegalovirus (HCMV) strains on the outcome of HCMV disease is poorly explored. The present study was undertaken to explore the role of gB genotypes with clinical features in infants with clinically suspected HCMV disease. Urine s...

Introduction: The Rubella virus has a worldwide occurrence and congenital syndromes are widely recognized as an emerging infection in several parts of the world. Miscarriage, perinatal mortality, stillbirth can develop pregnancy during first trimester. most frequent techniques for laboratory diagnosis IgM IgG-based serological detection methods. Such viral bacterial pathogen emphasizes developm...